Microbiome-Based Cellular Regeneration
Harnessing bio-active nanovesicles derived from Lactobacillus paracasei to restore your skin's natural balance through probiotic-derived nanovesicle science. True regeneration begins where science meets purity.
Where Microbiome Science
Meets Cellular Renewal
The human body hosts over 100 trillion microbial cells — three times more than human cells. Among these, Lactobacillus paracasei plays a foundational role in skin health, forming 90% of the birth canal microbiome and establishing the skin's protective barrier from the very first moments of life.
The Skin Microbiome & Dysbiosis
When the skin microbiome falls out of balance — a state known as microbial dysbiosis — the consequences extend beyond the skin surface. Disruption of the microbiome is linked to conditions including atopic dermatitis, accelerated aging, chronic inflammation, and compromised barrier function.
LactoReborn™ works at the root of this imbalance. By delivering bio-active extracellular vesicles (EVs) derived from L. paracasei, it restores the signaling environment that healthy skin depends on — without the risks associated with live bacteria or synthetic compounds.
"Lactobacillus paracasei makes up 90% of the birth canal's microbiome at the end of pregnancy — its extracellular vesicles help the newborn develop a healthy skin barrier."
Extracellular Vesicles: Nature's Delivery System
50–200nm Nanovesicles
Naturally sized to penetrate the dermal layer — reaching the endomembrane system including endoplasmic reticulum, mitochondria, and lysosomes.
Cell-to-Cell Messengers
EVs act as intelligent messengers, delivering bioactive cargo directly to target cells — activating regenerative pathways without genetic material.
Superior Safety Profile
No risk of uncontrollable proliferation. No genetic material. Derived from commensal bacteria with minimal safety concerns — ideal for sensitive skin.
Multimodal Mode of Action
Operates through diverse pathways simultaneously — anti-inflammatory, collagen synthesis, antioxidant, stem cell proliferation, and mitochondrial homeostasis.
cGMP Production
Produced in a certified cGMP-level in-house facility. The LactoReborn MDHC-011 strain ensures batch-to-batch consistency and cosmetic-grade quality.
Peptidoglycan Stability
LactoReborn membranes contain peptidoglycan — providing stability in acidic environments and resistance to digestive enzymes, unlike fragile human exosomes.
LactoReborn™ vs. Human Cell Exosomes
Microbial EVs establish a new benchmark in aesthetic medicine
Skin Penetration
LactoReborn™
Penetrates into the dermal layer — reaching fibroblasts and cellular organelles
Human Exosomes
Distributes only in the superficial epidermal layer
Antioxidant Activity
LactoReborn™
Comparable to Vitamin C; significantly superior to bone marrow, dermal fibroblast, and adipose stem cell exosomes
Human Exosomes
Lower antioxidant capacity across all tested exosome types
Production
LactoReborn™
Higher yield, cost-effective cGMP production, excellent storage stability
Human Exosomes
Low yield, high production cost, storage and stability challenges
Safety
LactoReborn™
No genetic material, no proliferation risk, commensal-derived
Human Exosomes
Risk of unintended genetic changes, proliferation concerns
Science-Backed Results,
Measurably Superior
LactoReborn™ efficacy has been validated across multiple peer-reviewed studies and clinical assessments, demonstrating results that surpass conventional treatments including retinoic acid (RA) and human stem cell exosomes.
Mode of Action: Anti-Aging & Rejuvenation
LactoReborn™ addresses aging at its molecular roots — recovering protein and mitochondrial homeostasis disrupted by biological, chemical, physical, and psychological stress.
UPR Activation
Augments unfolded protein response against ER stress — activating IRE-1, PERK, and ATF-6 sensors
AMPK Pathway
Enhances mitochondrial biogenesis and function via AMPK-mediated autophagy
Proteostasis
Rescues loss of proteostasis — a key hallmark of aging — in validated C. elegans models
Stem Cell Boost
Proliferates human stem cells in a dose-dependent manner, accelerating differentiation
Key Efficacy Metrics
Compared against control products and benchmark substances
Wrinkle Improvement
Skin Elasticity
Absorption & Hydration
Brightening & Barrier
184%
Collagen Production Increase
Human dermal fibroblast collagen production (COL1A1) — superior to TGF-β at 5ng/ml
>RA
Superior to Retinoic Acid
Anti-apoptotic and collagen synthesis efficacy surpasses all-trans-retinoic acid in inflammatory conditions
Dermal
Deep Penetration
Penetrates through the epidermal-dermal junction — reaching mitochondria, ER, and lysosomes
See the Results for Yourself
View real-world clinical before & after photography from LactoReborn™ treatments.
See How LactoReborn™ Compares
Side-by-side analysis vs. Resilielle, BENEV, Evolutionary Biologics & Rejuvion — including regulatory standing and clinical evidence ratings.
Anti-Aging Bioactive Molecules in LactoReborn™
Six naturally occurring compounds working in concert
D-Lactic Acid
- Blocks oxidative stress
- Improves mitochondrial function
- Promotes stem cell proliferation
Esculin
- Blocks oxidative stress
- Enhances proteostasis
Genistein
- Blocks oxidative stress
- Improves mitochondrial function
- Enhances proteostasis
Dodecanoic Acid (C12)
- Improves mitochondrial function
- Enhances autophagy
Palmitoleic Acid (Omega-7)
- Enhances proteostasis
- Enhances autophagy
- Promotes stem cell proliferation
Tagatose
- Blocks oxidative stress
- Improves mitochondrial function
- Enhances autophagy
Rebirth of Your
Skin's Ecosystem
A precision two-step professional treatment system delivering L. paracasei extracellular nanovesicles directly to the dermal layer — where cellular regeneration begins.
Lyophilized Powder
L. Paracasei Extracellular Nanovesicles
Freeze-dried (lyophilized) powder containing concentrated L. paracasei extracellular nanovesicles. Lyophilization preserves maximum bioactivity while ensuring exceptional stability and shelf life without refrigeration.
- 50–200nm nanovesicle size range
- Preserved bioactive cargo integrity
- Stable at ambient temperature
- cGMP-certified production
Ampoule Booster Solution
LactoReborn™ Activation Booster
The proprietary booster solution activates and enhances the nanovesicle payload, optimizing penetration depth and cellular uptake. Formulated to work synergistically with Step 1 for maximum regenerative effect across 10 treatment sessions.
- Activates lyophilized nanovesicles
- Enhances dermal penetration depth
- Optimizes cellular uptake efficiency
- 10-session professional treatment protocol
Active Ingredient
L. paracasei MDHC-011 EVs
Nanovesicle Size
50–200 nanometers
Treatment Protocol
10 professional sessions
Origin
100% Natural, cGMP Certified
Proven by Rigorous
Clinical Studies
Every efficacy claim is backed by peer-reviewed research and controlled clinical assessments. The data below represents results from validated studies using standardized measurement protocols.
| Category | Measurement | Result | Benchmark |
|---|---|---|---|
| Wrinkle Improvement | Forehead expression lines | 13.68% improvement | Control product (Niacinamide + Adenosine) |
| Fine lines around eyes | 11.49% improvement | Control product | |
| Thick wrinkles around mouth | 19.84% improvement | Control product | |
| Antioxidant | vs. Control product | 1.64× superior | Control product |
| vs. Ascorbic acid (Vitamin C) | Superior efficacy | Ascorbic acid | |
| Skin Elasticity & Collagen | Skin elasticity age index | 9.82% improvement | Control product |
| Skin lifting (elasticity) effect | 27.67% improvement | Control product | |
| Skin density improvement | 23.44% improvement | Control product | |
| Collagen production (human dermal fibroblast) | 184.03% increase | Superior vs. TGF-β 5ng/ml | |
| Collagen protein production | 209.70% increase | Superior vs. TGF-β 5ng/ml | |
| COL1A1 protein fluorescent expression | 213.47% increase | Superior vs. TGF-β 5ng/ml | |
| Elastin protein fluorescent expression | 146.65% increase | Superior vs. TGF-β 5ng/ml | |
| Absorption & Moisturizing | Skin absorption rate | 76.75% (1.90× vs. control) | Control product |
| Absorption speed & depth | 149.29% (2.76× vs. control) | Control product | |
| Skin moisturizing (20 layers) | 13.23% increase after 1 application | Control product | |
| Brightening | Tyrosinase mRNA expression inhibition | 41.33 ± 3.77% decrease | Superior vs. Arbutin |
| Barrier Enhancement | Transdermal water loss improvement | 53.33% improvement after 1 use | Control product |
*Control product: Wrinkle improvement & whitening dual-functional product with equivalent Niacinamide and Adenosine content
Research References
- [1]
L. paracasei EV attenuate the intestinal inflammatory response by augmenting ER stress pathway. Exp Mol Med 2020
- [2]
Human Probiotic L. paracasei EV improve TNF-α induced inflammatory phenotypes in human skin. Cells 2023
- [3]
A new horizon of precision medicine: combination of the microbiome and extracellular vesicles. Exp Mol Med 2022
- [4]
Lactobacillus-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived EVs. Allergy Asthma Immunol Res 2018
- [5]
Microbial Dysbiosis in the Skin Microbiome and Its Psychological Consequences. Microorganisms 2024
- [6]
EV from Lactobacillus paracasei-derived EV prime stem cells to accelerate stem cell differentiation via mitochondrial biogenesis. JEV (in submission)
Bring LactoReborn™
to Your Practice
LactoReborn™ is available exclusively through licensed aesthetic and medical professionals. Contact our team to learn about treatment protocols, training, and partnership opportunities.
Agnes Medical America
Exclusive distributor of LactoReborn™ in the United States
Professional Use Only
Available exclusively to licensed aesthetic and medical practitioners
Direct Contact
Training & Education
Comprehensive treatment protocol training and ongoing clinical support